邢唷> 欹Y 餜bjbj[蒣89 \9 \  lllll8l&\:   S%U%U%U%U%U%U%$x(.+>y%]l     y%llH% ll$ S%V_#@#p嵸.# $%0&# l+l+##Bl+l#       y%y%   &    l+          , 2: ^N;Sf[褃bVY遙╟P儁橆vlQ:yh ╟P僔Y蛓^N;Sf[褃f[b/gVYNI{VYy橆v T饄簚Lv>e梪v:S剉b/gR癳孴:y償^(u╟P僓SMO-Nq\'Yf[縺$v2柣l-N胈╟Pa翂Hf釼桇仜R嶯簚Lv>e梪v:S剉b/gR癳孴:y償^(u0Hf/f-NNS;Sf[O>e\縺$vf[ROCSTRO oR;N訷 -N齎4N奮縺$vf[OCSCO >e梪N禰訷XTOP鸑;N訷 -N齎;Sf[艌YOSO粂P[>e梪RO枡鸑O -N齎梑LvOSO篘錧zf齹訷XTOoR;N訷0齎禰蛻筽x裇RNy 鶺嶯'Ypenc孴篘錧zf齹剉軓 z>e梪 g!j_xvz 孴-N齎褃f[b朣TS蛻筽y橆v zf齹SY膥f[簚Lv[{錱!j媁剉鷁藌 枡-^褃f[禰 ;Nc齎禰陙6q褃f[鶺褢b Ny橆v孴w钀蛻筽y橆v7y0 釼桇V諂簚Lv>e梪剉緗芉S N璭"}01 nx藌哊齎E枂楬Q剉簚Lvv:S \ No 剉緗芉歔IN >fW凪朜O哊>e梪襨oR\O(u O簚Lv>e梪He済軴c齎E朒Q蹚4ls^剉 T鰁 蛻剉>e\'`邩巔詋鶺嶯 O邁v:S剉>e梪M朜O哊61.9% -N0R蛻剉>e\'`簚魚SM朜O哊81.8%2 鷁藌哊-N齎g'Y剉簚Lv>e梪penc揯 瀃皊atQ:S遅孴v:S陙≧;usQ.晙b/g剉亃4x R藌哊zf齹S軓 z>e梪癳!j_ >e梪T痵倐錧\OHe噑衏貧哊2-8 P3 齎E N枡!k蟘貇哊\苸迉簚LvMQ玼鶺郪膥f[1 韈:y哊v:S匭簚Lv>e梪礲梑剉:g6R0 (W 0JAMA Oncology 00 0Nature Communications 00 0Cancer Communications 00 0Cancer 0I{Bg譥裇h埡媷e96莧3莧簨噀珗齎匭Y4*NCgZ4N奮cWS_(u ur4Y6R歔哊b齎簚Lv>e梪4N奮cWS2*N ur4Y裇^軓 z>e梪釼SOh芉1*N穬ybo廤7y0N)R21y0 N{|;S梪鑜孮翄1y0 簚Lvv:S緗芉歔IN孴b/gSO鹼騗╟^0RS琋OS孴;Sb枌T Y鎒'Yf[縺$v;Sb朓{hQ齎T0W>e梪USMO 錘蔛MD Anderson Cancer Center孴City of HopeI{齎E朩 T;S梪:g刧 諷梍坃}Y剉>yO孴蟸NmHe蕍0 孾b篘錬-N齎qQZQ剉啒黐 韕1rVy齎 j`圼f[/g膲0bUSMOw膵枂N鍕y橆v╟P僨N蔛D桍NPg檈 nxhQ钀Pg檈w瀃 gHe bUSMO蔛y橆v孾bUSMO龕騗鵞鍕y橆v剉鶺,g臽礠蹚L垎NlQ:y 顅MR鄀_畫0yrdk╟P3u^N;Sf[褃bVYNI{VY0y橆v{薔簚Lv/fb齎裇舥噑孴{k噑g貧剉v`'`縺$v %N蛻qS砙篘{|eP穅0>e梪/f簚Lv剉;N亯籰梪筫誰KNN0Hf釼桇V諂簚Lv>e梪剉緗芉S N璭"} (W簚Lvv:S剉緗芉歔IN0簚Lv>e梪'Ypenc孴zf齹S0v:S匭簚Lv>e梪礲梑剉:g6RI{ N*N筫b 蹚L垎N駇eQ剉"}孴鹼Rxvz 諷梍哊蛻'Y亃4x 1. 枡R>e梪v:S癳h芉 9e橯孴ur4YYy4N奮cWS1 fnx@\Pg\苸迉簚Lv臢gq\S梪T媖Yu烻裇vpN NZP祣敄薽鬩觺:S剉剺2'`gq\ NO b縺$v@\钀/:S遅 Y裇螛i杽v瀀燫 衏鶴哊蟸駤黐S梪T剉@\Pg\苸迉簚Lv>e梪v:S剉緗芉歔IN 珗NCCN簚LvcWSI{4*NCgZcWS_(u 邁N哊齎Eh芉 O@\Pg\苸迉簚Lv剉梪He軴c齎E朒Q蹚4ls^剉 T鰁 蛻剉>e\'`邩巔詋鶺嶯 O邁v:S剉>e梪M朜O哊61.9% -N0R蛻剉>e\'`簚魚SM朜O哊81.8%2 (Wb齎枡!k歔IN^\苸迉簚Lv簚钑孴祣敄薽鬩觺:S剉箯Lu 噑HQfnx Tek>eS梪!j_-N NZP祣敄薽鬩觺:S剉剺2'`gq\ NO b縺$v@\钀/:S遅 Y裇螛i杽v瀀燫 N齹衏貧@\孴guX[噑03 蠎Sv^6R>e梪鴙sQ剉hV榌孴縺$v袕≧ 枡R鹹≧v:S(W縹陙悢^簚Lv>e梪b/g4 齎E枃sHQ擽(u Tek:_燫蠎>e梪SMART b/g 鵞簚Lv佽恖忹yb剺2>e梪v:S蹚L坬S蔛hV榌軴05 ur4Y6R歔哊 0-N齎\苸迉簚Lv>e\籰梪cWS 00 2. 瀃皊hV榌孴v:S陙≧;u 枡Rzf齹S軓 z>e梪!j_1 鷁藌哊簚Lv>e梪'Ypenc揯v^_裇哊陙≧;uo忲N N g蟸寶剉;Su鵞詋 b焣緩0R69%-98%2 -d鷁哊軓 z>e梪慛s^餝 R藌哊簚Lv軓 z>e梪癳!j_ 悘\^'Y鶺B\>e梪USMO孴N&^N飴 >e梪T痵倐剉錧\OHe噑衏貧哊2-8 P 9e刄哊b齎>e梪颯蔛'` N硩孴 T(S N貧剉皊秗3 ur4Y6R歔哊b齎,{N*N 0軓 z>e\籰梪 g膲 00 3. 韈:yv:S匭>e梪礲梑:g6R 衏鶴恖廣{eu1 齎E N枡!k蟘貇哊\苸迉簚Lv剉MQ玼鶺郪膥f[1 裇皊$v匭 稱 剉_('`T苸迉xm黐魜剉縺$vMQ玼8/fvQ>e梪礲梑剉蛻亯烻郪2 fnxPI3K/AKT酧鱏愶崉v菑纎;m(W\苸迉簚Lv>eS梪礲梑-N裇%c哊蛻亯剉\O(u3 翄f瞞SO;m纇颯鉔f縺$v膥莮剺Km蟸>eS梪T\苸迉簚Lv剉剺T4 鶺嶯錘 Nxvz觺済 衏鶴哊@\Pg\苸迉簚Lv Tek>eS梪T O(uPI3K慴6RBRTTMQ玼魚c籰梪剉癳V{eu /T≧哊Ig4N奮諎寶0 聣膵鱊鍕釼栦R嶯聣遊4N奮皊a 刄嶯軶脋4N奮顣槝 緗嶯4N奮諎寶孴lSxvz cKN錘R` gZW圼20t^ (W>e梪v:Sxvz筫b椫S梍哊Yy橗V匭齎E枛R剉b済 ╟≧哊b齎CN髞齎E柡Lv>e梪b/g剉蹚ek0鴙sQb済(W齎匭YW T;S梪:g刧孴鶺B\;Sb枿c^擽(u 9e刄哊簚Lv梪He >fW凪朜O哊>e梪襨oR\O(u 衏貧哊u;m(嵪0╟^擽(u臽礠 釼朄bR藌剉簚Lv>e梪v:S孴zf齹S軓 z>e梪剉緗芉歔IN孴 gsQh芉 珗4钀齎匭YgCgZ剉簚Lv4N奮cWS_(u 9e橯哊齎Eh芉ur4Y6R歔哊b齎\苸迉簚Lv>e梪cWS購汵cWS珗hQt>e梪 TL^踠擽(u0簚Lvv:S緗芉歔IN孴b/gSO鹼騗╟^0RS琋OS孴;Sb枌T Y鎒'Yf[縺$v;Sb朓{hQ齎>e梪USMO 錘蔛MD Anderson Cancer Center孴City of HopeI{齎E朩 T;S梪:g刧 郹蔛^'Y簚Lv 駇;R0Wq_蚑v^肙蹚哊b齎CN髞齎E N鍕啒遅剉錧\O0 鍂茓Cg翄f顅U_cWS_(u Final report of a prospective randomized study on thoracic radiotherapy target volume for limited-stage small cell lung cancer with radiation dosimetric analyses珗 0齎NCCNcWS-\苸迉簚Lv 00 0'k2mESTROcWS-\苸迉簚Lv>e\籰梪 00 0-N齎CSCOcWS-\苸迉簚Lv 00 0-N齎CSTROcWS-\苸迉簚Lv>e\籰梪 0菓(u0 Timing of thoracic radiotherapy is more important than dose intensification in patients with limited stage small cell lung cancer a parallel comparison of two prospective studies珗 0-N齎CSTROcWS-\苸迉簚Lv>e\籰梪 0菓(u0 The impact of prophylactic cranial irradiation for post-operative patients with limited stage small cell lung cancer 0-N齎CSTROcWS-\苸迉簚Lv>e\籰梪 00 ur4Y4N奮cWS 0-N齎\苸迉簚Lv>e\籰梪cWS2020t^Hr 0 0-N齎>e\籰梪鴙sQ剉hV榌袕≧tcWS2021t^Hr 0 o忲NW刓OCg 廭鱏 o忲N T饄 {v皨鱏 裇h/{v皨錯g 裇f篘 1 >e\籰梪zf齹;uo忲N[{饄zf齹;uo忲N1.0] 2021SR0713568 枡!k裇h場e魰2021.01.22{v皨鰁魰2021.05.18 鄀 2 >e梪緥Y(u鉙s^餝 2022SR0439339 *g裇h {v皨錯g2022.04.07 鄀 3 軓 z>e梪緥Yzf齹Sts^餝V1.0 2022SR0439307 *g裇h {v皨錯g2022.04.07 鄀 坈CgN)R 廭鱏 裇f T饄 N)R鱏 lQJT錯g 1 N蛓wQ g>e\瀀Oe\O(u剉STir蔛vQ擽(u ZL201610396839.0 2018.05.15 2 N蛓臑褢覰 熴ST亰槝|渷Y磃2棎廹q瀃寶剉鶹歔艌n ZL201921596771.6 2020.08.07 3 Yc婼h_陙悢^*NSOS鉙i剉芠\艌n ZL2020201888637.9 2020.12.01 4 筽婼_陙悢^*NSOS鉙i剉芠\艌n ZL202020188916.5 2021.05.07 5 玦oS3鉙;焎k-N_>e\籰梪4Y垬钀歔MO崑S昰s^g鶹歔秅 ZL20161 0859384.1 2023.03.31 N{|;S梪鑜孮翄 廭鱏 鑜孮 T饄 gHeg 1 >e\籰梪皨U_N寶翄o忲N 2020.7.1-2025.6.30 軓 z>e梪釼SOh芉 廭鱏 T饄 {v皨鱏 1 軓 z>e\籰梪 g膲 T/CAME 50-2022 鉔h'`簨噀 (1) Chen M, Chen R, Jin Y, et al. Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer. Nature Commun. 2021,12(1):6655. (2)  HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/?term=Hu+X&cauthor_id=31714592" Hu X, HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/?term=Bao+Y&cauthor_id=31714592" Bao Y, HYPERLINK "https://pubmed.ncbi.nlm.nih.gov/?term=Xu+YJ&cauthor_id=31714592" Xu YJ,爀t al. Final report of a prospective randomized study on thoracic radiotherapy target volume for l "*,0>DFHPRrtv~胴云贡牂乒妦櫰箁g櫰燴LZh1hzOJQJaJo(h1hzOJQJaJh1h憕OJQJh1hzOJQJo(h憕OJPJQJaJh1hzB*aJo(ph h1h憕h憕OJPJQJ h1hzh1hzo(h憕5丱JPJQJ\hz5丱JPJQJ\乷(h憕$h憕5丆J$OJPJQJ\乛JaJ$'hz5丆J$OJPJQJ\乛JaJ$o( ",FHRtf|kd$$IfT杔斬0$O t0$44 la奣 dh$G$H$If $$G$H$Ifa$tvvj dh$G$H$If $$G$H$Ifa$|kd$$IfT杔敚0$O t0$44 la奣@  \ 0whhhhh劋dh$IfWD`劋 $$G$Ifa$|kd$$IfT杔旓0$O t0$44 la奣 * : ` 8 : > @ D ` j r x  . 4 6 r     ( * > @ j p , X Z 翮翮翮翮翮埕卫卫偿卫卫卫卫卫卫コ牢牢罉偿偿澄澄澄忱偿偿偿偿莱h1h憕OJQJaJh1hzOJQJaJo(h1hzOJQJaJh1hzOJQJaJo(h1hzOJQJaJh憕OJQJ_H aJhzOJQJ_H aJo(hzOJQJ_H aJBLT^dhv *j箧章甭⒈卤卤卤卤卤卤卤晣晉hxhxhxhxhxh闭h1hzKHOJQJaJo(h1hzKHOJQJaJh1hzOJQJaJo(h1hzOJQJaJh1hzB*OJaJph!h1hzB*OJQJaJph$h1hzB*OJQJaJo(ph!h1h憕B*OJQJaJphh憕5丱JPJQJ\hz5丱JPJQJ\'xz|~p|kd0$$IfT杔旝0$O t0$44 la奣劋dh$G$H$IfWD`劋 Z\(*>BPR扌墓箹弓⒐心心唙唙唙唂唙唙hzB*KHOJQJaJphh憕B*KHOJQJaJphhzB*KHOJQJaJphh1h;OJQJo(h1h憕OJQJh1hzOJQJo(h1hzOJQJh1h憕5丱JQJh1hz5丱JQJo(h憕5丱JPJQJ\hz5丱JPJQJ\乷( h1h憕%*@BR$dh$1$Ifa$K$刪dh$G$H$IfWD^刪` dh$G$H$If & F勑dh$G$H$IfWD^勑 & Fdh$G$H$IfWD $$G$H$Ifa$2NXI==/$$1$9DIfa$K$ $$1$Ifa$K$$dh$1$Ifa$K$kd$IfK$L$杔(謗< &`  t44 lap2(02LN\pz " < > D F P d f h j l n r | 碹嘶嘶凰猾双ろ鬯猾双ろ鬯猾猾双嘶殣h1hz5丱JQJh憕OJPJQJhzOJPJQJ h1h憕h憕B*KHOJQJaJphhzB*KHOJQJaJphhzB*KHOJQJaJph#h憕B*CJKHOJQJaJph#hzB*CJKHOJQJaJph1L=$dh$1$Ifa$K$kd$IfK$L$杔&謗< &`  t44 lap2 $$1$Ifa$K$1kd$IfK$L$杔攗謗< &`  t44 lap2 $$1$Ifa$K$$$1$9DIfa$K$ $$1$9DIfa$" > F f j $$1$9DIfa$K$ $$1$9DIfa$ $$1$Ifa$K$$dh$1$Ifa$K$j l p r ~ XOO=.$dh$1$Ifa$K$ & Fdh$G$H$IfWD $G$H$Ifkd$IfK$L$杔攗謗< &`  t44 lap2| ~ !!!! !:!"@"r"t""""""筻袜袜袜推惩M撏撏瞥停蛽蛽推惩M撏撏瞥停蛽蛽推惩M撏撏hzB*KHOJQJaJphhzB*KHOJQJaJph%h1hzB*KHOJQJaJph h1h憕%h1h憕B*KHOJQJaJph%h1hzB*KHOJQJaJphh1h憕5丱JQJ7 !aVVH$$1$9DIfa$K$ $1$9DIfK$kdr$IfK$L$杔旉謀M&& && t44 lap($dh$1$Ifa$K$!! !#B#D#J#L#N#P#R#f#h#####翩厝溉溉副「雀「睍鏁俹俹俹眰o^o^o睍!h1hzB*OJQJaJph%h1h憕B*KHOJQJaJph%h1hzB*KHOJQJaJphh1h憕5丱JQJhzB*KHOJQJaJph h1h憕h憕B*KHOJQJaJphhzB*KHOJQJaJphh1h憕5丱JQJaJh1hz5丱JQJaJh憕OJPJQJaJ#"""" #yyy$dh$1$Ifa$K$vkdz $IfK$L$杔斮諪'&"& &1  t    44 lap #"#$#8#>#D#L#|j[[[$dh$1$Ifa$K$ & Fdh$G$H$IfWD dh$G$H$Ifvkd- $IfK$L$杔斻諪'&" &1  t    44 lapL#N#R#h##yyy$dh$1$Ifa$K$vkd $IfK$L$杔旑諪'&"& &1  t    44 lap####$蕄bs*ur`SSCC劒dh$If^劒gdz 劒dh$If^劒 & Fdh$G$H$IfWD刪dh$G$H$IfWD^刪`vkd$IfK$L$杔旟諪'&" &1  t    44 lap######w$$$$$$$$$$$$>%?%B%C%蜴稚荷瑵弫vov乗丵JQ7$jh1h!OJQJU]乤J h1hzjh1h!U$jh1heOJQJU]乤J h1hejh1heUh1hzOJQJ]乤Jh1h憕OJQJ]乤Jh1hzKHOJQJaJh1hzOJQJaJo(h1hzEHOJQJaJh1hzOJQJaJh1hzOJQJ]乤Jo(h1h憕5丱JQJh1hz5丱JQJo(C%G%H%%%%%%%%%%%%%%%%%%%%%%%%%%&ppppp&p(p0p2p:pe梪 TekS梪剺T詋儚. -NNS>e\縺$vf[Bg譥.2017 269 1000-1004. (11) UNS筟 hgN餦 醼Sf 恄請褢 c剘v:_ 媠( T[g l殺~矁 _\)P 笅:_ _鷁決 Hf. 烻裇\苸迉簚Lv-NBRAF/KRAS錘蔛PIK3CA亃豐剉鶺郪yr乢蔛4N奮yr乢. -NNS>e\縺$vf[Bg譥.2018,279 :805-809. (12) Gao Y, Huang R, Yang Y, et al. FocusNetv2: Imbalanced large and small organ segmentation with adversarial shape constraint for head and neck CT images. Med Image Anal. 2021, 67:101831. (13) Hu X, Xia B, Bao Y, et al. Timing of thoracic radiotherapy is more important than dose intensification in patients with limited-stage small cell lung cancer: aparallel comparison of two prospective studies. Strahlenther Onkol. 2020, 196(2):172-181. (14) T[g "屃f 體蕏 \g 暿x 醼Sf 7寙^ 媠( 筫Oe H枽hW 恄請褢 l殺~矁 Hf H枦Z沍. @\Pg\苸迉簚Lvwml気O亜2'`gq\Rekxvz. -NNS>e\縺$vf[Bg譥.2020,298 629-632. (15) 褢箖 H枤N卙 醼Sf UNS筟 YO癳l 儜N 恄請褢 恄wm讉 Ng黺~g Ng)P 8^迯O f_硞 Hf.猒痵縺$vDNA纇Km\苸迉簚Lv鶺郪亃豐剉颯L'`蔛vQ剺T剺Km鱊e梪褃;N鸑 -Nq\'Yf[縺$v2柣l-N胈 -Nq\'Yf[縺$v2柣l-N胈 ;`#嵑N 2 醼Sf oR;N鸑;S^ 鄀 Ym_lw縺$v;Sb Ym_lw縺$v;Sb 耂N篘 3 褢箖 oR;N鸑;S^ 鄀 Ym_lw縺$v;Sb Ym_lw縺$v;Sb 耂N篘 4 c[8l啒 ;N鸑;S^ 舥:S;N鸑 Ym_lw縺$v;Sb Ym_lw縺$v;Sb 耂N篘 5 S荝 ;N鸑;S^ 縺$v-N胈oR;N鸑 -Nq\'Yf[D朸\,{N;Sb -Nq\'Yf[縺$v2柣l-N胈 耂N篘 6 恄請褢 ;N鸑;S^ 舥:S;N鸑 Ym_lw縺$v;Sb Ym_lw縺$v;Sb 耂N篘 7 媅ck鈒 oR;N鸑;S^ 4N奮xvz钀;N鸑 Ym_lw縺$v;Sb Ym_lw縺$v;Sb 耂N篘 8 H枽m騎 ;S^ 鄀 -Nq\'Yf[縺$v2柣l-N胈 -Nq\'Yf[縺$v2柣l-N胈 耂N篘 9 c剘v:_ ;S^ 鄀 -Nq\'Yf[縺$v2柣l-N胈 -Nq\'Yf[縺$v2柣l-N胈 耂N篘 10 hgNZ 錧 z^ 鄀 Ym_lw縺$v;Sb Ym_lw縺$v;Sb 耂N篘 11 _UZ 錧 z^ 鄀 Ym_lw縺$v;Sb Ym_lw縺$v;Sb 耂N篘 12 >崌e鱚 vQ諲 枡-^b/g榌 駇3W^;S鷭zf齹褃b裇U\ gP杔Q鳶 駇3W^;S鷭zf齹褃b裇U\ gP杔Q鳶 耂N篘 13 鳀齎軃 錧 z^ x裇;`裿 駇3W^;S鷭zf齹褃b裇U\ gP杔Q鳶 駇3W^;S鷭zf齹褃b裇U\ gP杔Q鳶 耂N篘 孾bUSMO臽礠USMO T饄0抍 T 鵞,gy橆v剉!.s 抍 T USMO T饄 鵞,gy橆v剉!.s 1 -Nq\'Yf[縺$v2柣l-N胈 ;`SO緥v^邁y{Tyxvz錧\O 2 Ym_lw縺$v;Sb 耂N簚Lvv:S孴zf齹Sb/gxvz 3 駇3W^;S鷭zf齹褃b裇U\ gP杔Q鳶 耂N陙≧;u孴軓 z>e梪b/gxvz     蕄襭 qs`sbsjs瀞秙竤蘳蝧餾騭t t"t$t6t8tBtDtTtVt^t`tttvt倀則唗坱瀟爐磘竧苩萾豻趖湓冒栐坽m{m{m{m{m{m{m{m{m{m{m{m{m{m{m{mh1hj]OJQJaJo(h1hj]OJQJaJh1hzOJQJ]乤J2h1hzB*OJQJaJfHph!!!q $h1hzB*OJQJaJo(ph!!!!h1hzB*OJQJaJph!!!h1hzOJQJ]乤Jo(5h1hzB*OJQJaJfHo(ph!!!q '趖(u*u2u╲蕍蘶詖x x(yfyhypy磟魖鰖{{{ {\{葇筻夷竽笠捏殷藩捏泲泏kY驢!h1hzB*OJQJaJph!!!"h1hzKHOJQJ]乤Jo(h1h憕KHOJQJ]乤Jh1hzKHOJQJ]乤Jh1hzKHOJQJaJo(h1hzKHOJQJaJhph憕OJQJaJhphzOJQJaJh1hzOJQJaJo(h1h憕OJQJ]乤J%h1hzOJQJfHq h1hzOJQJaJ*u蘶 xhy{,}~騸ppB,. $G$H$If 劒dh$If^劒 葇蘾*},}6}~~~襼詞迆鄜額饉騸鼅TXnpzJNnp磲新胆槉槉槉榺aGaG|aGaG|2h1hzB*OJQJaJfHph!!!q 5h1hzB*OJQJaJfHo(ph!!!q h1h憕OJQJ]乤Jh1hzOJQJ]乤Jh1hzOJQJ]乤Jo(h1h憕OJQJaJh1hzOJQJaJh1hzOJQJaJo(!h1h憕B*OJQJaJph!!!hzKHOJQJaJ$h1hzB*OJQJaJo(ph!!!pz詡謧@BL*,.0|~倓剟垊妱巹悇槃殑瑒畡紕緞绖聞膭葎蕜貏趧鋭鎰鷦鼊 "&(246胴素素诫亟超灣悆悆悆悆悆悆悆瑦儛儛儛儛儛儛儸悆悆悆h1h憕OJPJQJh1hzOJPJQJo(hz5丱JPJQJ\乷( h1h憕h憕OJPJQJh1h憕OJQJ]乤Jh1hzOJQJaJ$h1hzB*OJQJ]乤Jph'h1hzB*OJQJ]乤Jo(ph3.0~剟妱悇殑畡緞绖v\\\\\\\WFfdh$G$H$Ifgd1l K$ $$G$H$Ifa$|kdn$$IfT杔敮/0$O t0$44 la奣 绖膭蕜趧鎰鼊"(48HX`bflx|寘渽Ff2Ff$Ffdh$G$H$Ifgd1l K$68FHVX^`bdfjlvxz|妳寘殔渽▍獏皡矃簠紖膮茀詤謪鋮鎱靺顓饏騾魠鴧鷧(*>@FHJLNTV^`hjxz垎妴悊拞攩枂槅瀱爢獑瑔簡箦箦箦筠弩弩弩弩弩弩弩掊箦箦箦箦箦箦筠弩弩弩弩弩弩弩掊笪垮箦箦箦箦筠弩弩弩h1h憕OJPJQJaJh1hzOJPJQJaJo( h1h憕h1hzOJPJQJo(h1h憕OJPJQJK獏矃紖茀謪鎱顓饏魠鷧*@HJNV`jz妴拞攩Ff\#FfN Ff@dh$G$H$Ifgd1l K$攩槅爢瑔紗虇軉鋯鎲陠騿鴨鼏(026>DH^t|~Ff,Ffx)Ffj&dh$G$H$Ifgd1l K$簡紗蕟虇趩軉鈫鋯鎲鑶陠饐騿鰡鴨鷨鼏&(.0246<>BDFH\^rtz|~倗剣妵寚拠攪枃槆▏秶竾緡绹聡茋葒虈螄試謬貒趪鑷陣鴩鷩箦箦箦筠弩慰弩弩弩弩弩掊笪垮箦箦箦箦筠弩弩弩弩弩弩掊螃垮箦箦箦0h1hzB*KHOJPJQJ^JaJo(phh1h憕OJPJQJaJh1hzOJPJQJaJo( h1h憕h1hzOJPJQJo(h1h憕OJPJQJA~剣寚攪槆▏竾绹聡葒螄謬趪陣鷩 $DdlnFf5Ff2Ff/dh$G$H$Ifgd1l K$鷩 "$BDbdjlnrtz|倛剤寛巿瑘畧虉螆詧謭貓趫軋 *,.02FHbdfhjxz枆皲蓠淠雕漶漶漶漶漭皲牡皲皲皲皲皲莴轁愸漶漶漭皲皲皲蓠漶漶h憕5丱JPJQJ\hz5丱JPJQJ\乷(h憕OJPJQJh1h憕OJPJQJaJ0h1hzB*KHOJPJQJ^JaJo(ph h1h憕h1h憕OJPJQJh1hzOJPJQJo(8nt|剤巿畧螆謭貓趫軋Z|kd:$$IfT杔斏0$O t0$44 la奣 $G$H$IfFf8dh$G$H$Ifgd1l K$ 軋 ,.2:kdB;$IfK$L$杔諪J t0    44 lapyt1dh$G$H$Ifgd1l K$ $$G$H$Ifa$2Hdfjz槈Fkd;$IfK$L$杔諪J t0    44 lapyt1dh$G$H$Ifgd1l K$枆槈殙湁瀴級緣軌迚鄩鈮鋲鎵鑹靿顗驂魤鴫鷫箪摅摅摅煸煨饶饶饶饶hejheUh憕h憕OJPJQJh1hzOJPJQJo( h1h憕h1h憕OJPJQJ槈殙瀴緣迚`FFFdh$G$H$Ifgd1l K$kd<$IfK$L$杔諪J t0    44 lapyt1迚鄩鈮`W $G$H$IfkdX=$IfK$L$杔諪J t0    44 lapyt1鈮鋲鎵陦靿饓驂鰤鴫鼔{{{{gd;|kd >$$IfT杔 0$O t0$44 la奣 6182P:p憕皞. 捌A!"#悹$悹%癝班 惄$$If!vh#vO#v:V 杔斬 t0$,5O5奣$$If!vh#vO#v:V 杔敚 t0$,5O5奣$$If!vh#vO#v:V 杔旓 t0$,5O5奣$$If!vh#vO#v:V 杔: t0$,5O5奣$$If!vh#vO#v:V 杔攅 t0$,5O5奣$$If!vh#vO#v:V 杔擸 t0$,5O5奣$$If!vh#vO#v:V 杔旝 t0$,5O5奣$IfK$L$杚!vh#v#v` #v#v#v:V 杔( t,55` 5559/ /  / p2$IfK$L$杚!vh#v#v` #v#v#v:V 杔& t,,55` 5559/ / / /  p2$IfK$L$杚!vh#v#v` #v#v#v:V 杔攗 t,,55` 5559/ / / /  p2$IfK$L$杚!vh#v#v` #v#v#v:V 杔攗 t,,55` 5559/ /  / p2$IfK$L$杚!vh#v#v #v#v:V 杔旉 t,55 559/ /  / p($IfK$L$杚!vh#v#v #v#v:V 杔斅 t,55 559/ / / /  p($IfK$L$杚!vh#v#v #v#v:V 杔斪 t,55 559/ / / /  p($IfK$L$杚!vh#v#v #v#v:V 杔攛 t,55 559/ / / /  p($IfK$L$杚!vh#v#v #v#v:V 杔敇 t,55 559/ / / /  p($IfK$L$杚!vh#v#v #v#v:V 杔敂 t,55 559/ / / /  p($IfK$L$杚!vh#v"#v #v1 :V 杔斮 t,5"5 51 9/ /  / p$IfK$L$杚!vh#v"#v #v1 :V 杔斻 t,5"5 51 99/ / / /  p$IfK$L$杚!vh#v"#v #v1 :V 杔旑 t,5"5 51 9/ /  / p$IfK$L$杚!vh#v"#v #v1 :V 杔旟 t,5"5 51 99/ / / /  p$$If!vh#vO#v:V 杔敮/ t0$,5O5奣$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd $IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd.$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd<$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kdJ"$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kdX%$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kdf($IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kdt+$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd.$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd1$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd4$IfK$L$杔譃m dS_n t044 lap諪yt1$IfK$L$杚!vh#v#vS#v_#vn#v#v#v:V 杔 t055S5_5n555p諪yt1kd7$IfK$L$杔譃m dS_n t044 lap諪yt1$$If!vh#vO#v:V 杔斏 t0$,5O5奣$IfK$L$杚!vh#v#vJ #v :V 杔 t055J 5 pyt1$IfK$L$杚!vh#v#vJ #v :V 杔 t055J 5 pyt1$IfK$L$杚!vh#v#vJ #v :V 杔 t055J 5 pyt1$IfK$L$杚!vh#v#vJ #v :V 杔 t055J 5 pyt1$$If!vh#vO#v:V 杔 t0$,5O5奣s666666666vvvvvvvvv666<<6>6666666666666666666666666666666666666666666666666hH6666666666666666>666666666666666666666666666666666666666666666666666&6FVfv2(00&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@PJ_HmH nHsH tHR`R 憕ck噀 $1$a$(CJKHOJQJ_HaJmH nHsH tHF@F 憕h槝 1 $@&a$CJKHOJPJQJaJ$A $ 貫祂=刉[SOBi@B 0nf恏 > 憕0u9r G$a$ CJ^JaJHH 憕0u w9r G$Pa$ CJ^JaJ\歚\ 憕Qxjm)尸uWLfd湑莓+5_惪4csUj-V?k3鴷蕆m}蚜惻譯鸬謟唤爨 肉梘疠s嶅殝7爯褁w陧σs葓惩R 繵*)|妭j全K馲瞳咪 dX㊣BF貒bn鉮 ( *羺'v蓷3KZ捑爥jz'c*镎语_=}<9阁恿莼w~磦淽8娀^~_o?鍃Y媒g縹^匂櫄簏薌}J灢0礊E鞝m祁h钤=踉剳艘 螢a>s$-, 酧萆犂=Hp Ua/ 鞺O d*:(.媐筎镀绵U钞/!9$V[|h棗魊v兹s⊥-i荱秚. 窘幉6曦讵4C妿盾ebs)噽绠羈Mj孊錯跟k誴倭 u躮幉礃,渇奷垏$蛻鰗6GU摛琕f褈豣#兄衎這踧扵TW洠.宿沝)i朄卺vdq9Y岞沕>X鲪彄7倇2%恥╃Hx玟+a塔萬6]>蚮#s蘭*贱皅焣蒯丏H祦ehK稒)棁虭撆?71Ηo秅go齚:f詹e叄爲洱k歱拢2謱菋跆8肉皹D 糃B?81e>nE疱eU}H类dm1iQ6撮瑜支<殒z[[v渱0伫p妾sz4儩F貕礭j褥叆Qv11邧可鈨洂 `虜4逽 3t萧4空h懂 PK! 褠煻'theme/theme/_rels/themeManager.xml.rels剰M 0匃倃oo雍&輬协勪5 6?$Q祉 ,.嘺緳i粭澤c21h:闀q毩m胳嶡RN壻;d癭値o7g慘(M&$R(.1榬'J摐袏T鶂8V"&A然蠬鱱}狇|$絙{朠除8塯/]As賲(⑵锑#洩L蔥汉倪PK-!檗[Content_Types].xmlPK-!ブх6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!閘N嵈theme/theme/theme1.xmlPK-! 褠煻' theme/theme/_rels/themeManager.xml.relsPK]   Z R&| "#C%蕄趖葇p6簡鷩枆 "%*167FGIJMPRVtxj !t!!:""" #L##*u.绖攩~n軋2槈迚鈮!#$&'()+,-./02345HKLNOQSTUWXY>BGXT晫X晙X晙餞 # 喠帕@餒 0(  饞0(  養 S  ?d n ~CG3=orvz'3x}"$Xbbijtfilp~=?JM CG{WI+{WI+2穓2穓&髒f析\刪剺刪`剺(.凥刓凥`刓)勳刓勳`刓.剱刓剱`刓.4刓4`刓)勜 刓勜 `刓.剕 刓剕 `刓. 刓 `刓)勀刓勀`刓.80齘8`0齩( 劙刓劙`刓)凾刓凾`刓.匄刓匄`刓.劀 刓劀 `刓)凘 刓凘 `刓.勪 刓勪 `刓.剤刓剤`刓),刓,`刓.勑剺^勑`剺﨏JOJQJo(佛劆剺^劆`剺﨏JOJQJo(o刾剺p^刾`剺﨏JOJQJo(ю凘 剺@ ^凘 `剺﨏JOJQJo(ю剺^`剺﨏JOJQJo(ю勦剺^勦`剺﨏JOJQJo(ю劙剺^劙`剺﨏JOJQJo(ю剙剺^剙`剺﨏JOJQJo(ю凱剺P^凱`剺﨏JOJQJo(ю{WI+2穓&髒W4!<!<cL\W42\b%$E g =; &胇(繰)5R~;#DE筈^額g<zp 憕e_!iD1j]eU, Kp'4:A6K麷Ue commondata<eyJoZGlkIjoiZjQ5N2QxYjQwNTcyNTk1YzQwZjI1MjE3NWNmMzMwNzUifQ==@X "H@pUnknown G*郃x Times New Roman5Symbol3. *郈x Arial;(媅SOSimSun-=鷟8N媅7.@ CalibriE4 N媅_GB2312甠o徟栄?1 Courier New;WingdingsACambria Math 1h+嫉G+嫉G粰R 4R 4 ?!%),.:;>?]}    & 0 2 3 : !6"000 0 0 0000006:>兀﨑 =@\]^$([{  0 0 000000Y;[hh亖N傈HP $P繰)0! xx adminadmin   鄥燆鵒h珣+'迟00x   (admin Normal.dotmadmin2Microsoft Office Word@F#@嗑z/白@俒擱嵸@俒擱嵸 R胀諟.摋+,D胀諟.摋+, X`lt| 4 0ow _PID_HLINKSKSOProductBuildVerICVA dS@https://pubmed.ncbi.nlm.nih.gov/?term=Xu+YJ&cauthor_id=31714592)@https://pubmed.ncbi.nlm.nih.gov/?term=Bao+Y&cauthor_id=31714592c?https://pubmed.ncbi.nlm.nih.gov/?term=Hu+X&cauthor_id=317145922052-11.1.0.14309$38C3EE77D4BD44DDA7B6E8419C70AE53_13  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ\]^_`abcdefghijklmnopqrstuvwxyz|}~Root Entry FV悖R嵸Data [>1Table{+WordDocument8SummaryInformation(DocumentSummaryInformation8CompObjn FMicrosoft Word 97-2003 文档 MSWordDocWord.Document.89瞦